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12-well PerfusionPal Plate by Lena Biosciences

$350.00$1,300.00

The 12-well PerfusionPal tray enables continuous perfusion of 12 statistically independent cell cultures

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Description

PerfusionPal by Lena Biosciences is the perfused multi-well tray used in the Perfused Organ Panel system that enables continuous perfusion of 12 statistically independent cultures with just one tube.

PerfusionPal is a unique Organ-on-a-Chip insert system that allows cells to be grown in an environment that mimics the human body. The exclusive design of the system enables continuous perfusion of up to 24 different tissue cultures (2 plates) at one time. The perfusion of media and blood substitute through the well plate emulates interstitial fluid flow in the body. This enables the exchange of nutrients, oxygen, and metabolites with the cells. The integration of fluid flow is crucial for maintaining the functionality of tissue. The cells respond to flow through differentiation and metabolic adaptation.

Cells are seeded on inert, glass-fiber scaffolds and maintained in statistically-independent wells, in their own medium that floats atop a high-density blood substitute in which medium and reagents are insoluble. The blood substitute dissolves much more atmospheric gas than aqueous medium can. Pumping of this blood substitute acts as a “liquid piston” that introduces perfusion into the system without the need for separate pumps and tubing for each culture.

Benefits:

  • Increases Phase I drug metabolism 2-5 times
  • Saves time and money compared to relay assay
  • Provides human metabolites for slow-to-metabolize drugs
  • Provides concentrated secretome to test biologics (monoclonal antibodies and antibody-drug conjugates)
  • Enables extended mechanistic studies and repeat-dose testing
  • Provides superior tissue oxygenation and pH maintenance
  • Prolongs cell viability and functionality
  • Offers more precision and control than animal models
  • Supports most cell types and extracellular matrices, including primary cells, iPSC and iPSC-derived cells, and immortalized cell lines

 

For single use only. Sterile.
Ships within 1 week.

1 Pack includes:

  1. PerfusionPal 12-well plate
  2. 15 SeedEZ scaffolds
  3. Tubing and syringe
  4. Luer Cap
  5. Seeding Insert

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4 Pack includes:

  1. PerfusionPal 12-well plate x 4
  2. 60 SeedEZ scaffolds
  3. Tubing x 4 and Syringe x 4
  4. Luer Cap x 4
  5. Seeding Insert x 4

 

Used with Lena Biosciences Perfused Organ Panel (Cat.#s: LB-2001-48/ LB-2001-12).

Additional information

Plate Quantity

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Specifications

Catalog Number LB-2012-01 / LB-2012-04
Lot Number Included with shipment
Country of Manufacture USA
Quantity 1-pack or 4-pack
Packaging Individually packaged
Material Hydrophilic polyester
Sterility Sterile
Features Used with SeedEZ scaffolds for cell culture [included in pack]
Shelf Life 2 years from receipt
Storage Room temperature
Shipping Info Ships from manufacturer [standard shipping within 1 week]
Product Use This product is for research use only. It is not approved for use in humans, animals, or for diagnostic procedures.
References Characterization of patient-derived organoids cultured on a gas-rich, liquid-liquid interface. Shoemaker JT, Richardson KR, Arnst J, Marcus AI and Vukasinovic J. ​American Association for Cancer Research 2019. Proceedings: Abstracts 1-2748.

Neuroimmune activation and off-target toxicity testing of cell therapies using a novel brain-on-a-chip system. J.T. Shoemaker, J. Vukasinovic, C. Xu, Z. Wen, and M.C. LaPlaca. Society for Neuroscience 2018.

Progress towards the development of a fully humanised 3D cell culture model of HER2+ breast cancer. Sophie Roberts, Danah Al’Qallaf, Sally A. Peyman, Darren Tomlinson, J.T. Shoemaker, Jelena Vukasinovic and Valerie Speirs. Breast Cancer Res Treat (2018) 167: 309. DOI: 10.1007/s10549-017-4585-x.

United States Patent No. 9,701,938

Technical Resources

12-Well Perfusion Plate Technical Data Sheet

All files supplied as PDFs