Human Bone Marrow-derived Mesenchymal Stem Cells

Human bone marrow-derived mesenchymal stem cells (hBM-MSCs) are multipotent stem cells with a high capacity for self-renewal and can develop into specialized cells of the body such as chondrocytes, osteoblasts and adipocytes. Bone marrow derived MSCs can also differentiate into nerve cells, heart muscle cells, liver cells, and endothelial cells. Their easy accessibility, exceptional genomic stability, and their capacity for tissue repair with few immunological and ethical issues make them a favorable cell type for experimental and clinical use. Many trials are underway using bone marrow mesenchymal stem cells to understand and treat osteoarthritis, sepsis, autoimmune diseases, graft versus host disease, Crohn’s disease, multiple sclerosis, systemic lupus erythematosus and systemic sclerosis.

Human bone marrow MSCs by JangoCell are isolated from adult female (single donor) human bone marrow aspirates from qualified, traceable donors. Cells are cultured, passaged for purity, cryopreserved, and delivered frozen. Each vial contains 1 x 10⁶ cells in 1 mL volume. Our human bone marrow-derived stem cells are characterized by flow cytometry and are negative for mycoplasma, yeast, fungi, and bacteria. HIV-1, HIV-2, and HBV are not detected. A certificate of analysis (CoA) is provided with each lot purchased. Additional donor information may be available when you place your order. Cells are assured to further culture using the protocol provided by JangoCell.

Bone marrow-derived mesenchymal stem cells (BM-MSCs) are also known as: BMMSCs, BMSCs, bone marrow-derived mesenchymal stromal cells, bone marrow stromal stem cells, bone marrow cells, bone mesenchymal stem cells, MSC cells, MSC stem cells, adult mesenchymal stem cells, and adult stem cells.

Product Use

This cell product is intended for laboratory research purposes only. Not approved for use in human subjects or for clinical, diagnostic, or therapeutic use in animals or humans.

Human Material Precaution

Tissues used for cell isolation were acquired with informed consent and adhere to HIPAA standards for human privacy protection. All human biological material, including human cells, should always be handled as potentially infectious using at least Biosafety Level 2 precautions; we recommend that appropriate safety procedures be followed, using the same biosafety protocol used with known infectious material. Viral testing cannot prove the absence of a latent viral genome.

Note: Image shown is representative of the cell product described but may not show the actual purchased product.

Additional information

Species/Breed	Human
Tissue	Bone Marrow
Age	Adult
Sex	Female

JangoCell Statement on Passage Number

While passage number is the de facto metric used for determining cell proliferation capacity, the actual capacity is dependent upon the total number of cell divisions (or population doubling number (PDN)) that a particular cell type can undergo. This can be illustrated with a simple example. Since stem cells are typically passaged upon reaching confluence, cells grown at low confluence in a flask or in a large vessel such as a bioreactor (large surface area to cell number) will require many more doublings to reach confluence before they are ‘passaged’ than cells seeded at high confluence. This can result in low passage numbers, but a cell population with more limited capacity for further cell division. Therefore, passage number is not the most reliable means of determining future cell proliferation capacity after purchase.

For these reasons, and to provide transparency concerning our cell products, JangoCell will express future cell division capacity, or the number of times that our cells will be able to divide and double in number after purchase (after thaw), in terms of population doubling number (PDN). We will express the current cell division number, or the number of times that our cells have already divided and doubled in number before cryopreservation, in terms of population doubling level (PDL). JangoCell’s primary stem cells when plated at ~20% confluency will display a PDN between 30-40 when cultured using the protocol recommended by JangoCell for each specific cell type.

Please see our page on passage number under Technical Resources for more information.

Catalog Number	BM-MSC-HF-02
Lot Number	Included with shipment
Country of Manufacture	USA
Quantity	1 x 10⁶ cells/vial
Storage	Immediately transfer cells from dry ice to liquid nitrogen upon arrival.
Shipping Info	Dry ice; Overnight shipping
Also Known As	BMMSCs, BMSCs, bone marrow-derived mesenchymal stromal cells, bone marrow stromal stem cells, bone marrow cells, bone mesenchymal stem cells, MSC cells, MSC stem cells, adult mesenchymal stem cells, and adult stem cells.
Product Use	This cell product is intended for laboratory research purposes only. Not approved for use in human subjects or for clinical, diagnostic, or therapeutic use in animals or humans.
References	Han Y, Li X, Zhang Y, Han Y, Chang F, and Ding J. Mesenchymal stem cells for regenerative medicine. Cells. 2019; 8(8):886. doi: 10.3390/cells8080886. Stoltz JF, de Isla N, Li YP, Bensoussan D, Zhang L, Huselstein C, Chen Y, Decot V, Magdalou J, Li N, Reppel L and He Y. Stem cells and regenerative medicine: Myth or reality of the 21th century. Stem Cells International. 2015; 734731. doi: 10.1155/2015/734731. Epub 2015 Aug 2. Sammour I, Somashekar S, Huang, J, Batlahally S, Breton, M, Valasaki K, Khan, A, Wu, S and Young kc. The effect of gender on mesenchymal stem cell (MSC) efficacy in neonatal hyperoxia-induced lung injury. Plos One 2016; 11(10): e0164269. doi: 10.1371/journal.pone.0164269.

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Human Bone Marrow-derived Mesenchymal Stem Cells – Adult Female

Additional information

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