Human Chorionic Plate-derived Mesenchymal Stem Cells

Placenta-derived mesenchymal stem cells (MSCs) are multipotent stem cells with a high capacity for self-renewal. Placenta mesenchymal stem cells can develop into specialized cells of the body such as chondrocytes, osteoblasts, and adipocytes, and their easy accessibility, exceptional genomic stability, and capacity for tissue repair with few immunological and ethical issues make them a favorable cell type for experimental and clinical use. Importantly, MSCs derived from neonatal tissues have shown greater proliferative capacity and lower immunogenicity than adult bone marrow-derived MSCs. Human chorionic plate-derived mesenchymal stem cells (hCP-MSCs; isolated from the fetal portion of the placenta) have been shown to exhibit better adipogenesis efficiency, greater clonogenic potential, and higher expression of genes related to cell cycle progression and genome stability than other placental tissues, and so are ideal for different experimental or clinical applications.

Human placental mesenchymal stem cells were isolated from the chorionic plate of the placenta (female offspring). The human placental cells are cultured, passaged for purity, cryopreserved, and delivered frozen. Each vial contains 1 x 10⁶ cells in 1 mL volume. Human placental MSC are characterized by flow cytometry for CD90, CD105, CD73, CD45, and CD34. hCP-MSCs are negative for mycoplasma, yeast, fungi, and bacteria. HIV-1, HIV-2, and HBV are not detected. Cells are assured to further culture using the protocol provided by JangoCell.

Human chorionic plate-derived mesenchymal stem cells (hCP-MSCs) are also known as: CP-MSCs, P-MSCs, pMSCs, chorionic MSCs, human chorionic-plate-derived MSCs, placenta tissue-derived MSCs, human placenta cells, human placental stem cells, stem cells from placenta, and placenta stem cells.

Product Use

This cell product is intended for laboratory research purposes only. Not approved for use in human subjects or for clinical, diagnostic, or therapeutic use in animals or humans.

Human Material Precaution

Tissues used for cell isolation were acquired with informed consent and adhere to HIPAA standards for human privacy protection. All human biological material, including human cells, should always be handled as potentially infectious using at least Biosafety Level 2 precautions; we recommend that appropriate safety procedures be followed, using the same biosafety protocol used with known infectious material. Viral testing cannot prove the absence of a latent viral genome.

Additional information

Species/Breed	Human
Tissue	Placenta
Age	Placental
Sex	Female

JangoCell Statement on Passage Number

While passage number is the de facto metric used for determining cell proliferation capacity, the actual capacity is dependent upon the total number of cell divisions (or population doubling number (PDN)) that a particular cell type can undergo. This can be illustrated with a simple example. Since stem cells are typically passaged upon reaching confluence, cells grown at low confluence in a flask or in a large vessel such as a bioreactor (large surface area to cell number) will require many more doublings to reach confluence before they are ‘passaged’ than cells seeded at high confluence. This can result in low passage numbers, but a cell population with more limited capacity for further cell division. Therefore, passage number is not the most reliable means of determining future cell proliferation capacity after purchase.

For these reasons, and to provide transparency concerning our cell products, JangoCell will express future cell division capacity, or the number of times that our cells will be able to divide and double in number after purchase (after thaw), in terms of population doubling number (PDN). We will express the current cell division number, or the number of times that our cells have already divided and doubled in number before cryopreservation, in terms of population doubling level (PDL). JangoCell’s primary stem cells when plated at ~20% confluency will display a PDN between 30-40 when cultured using the protocol recommended by JangoCell for each specific cell type.

Please see our page on passage number under Technical Resources for more information.

Catalog Number	CP-MSC-HF-05
Lot Number	Included with shipment
Country of Manufacture	USA
Quantity	1 x 10⁶ cells/vial
Storage	Immediately transfer cells from dry ice to liquid nitrogen upon arrival.
Shipping Info	Dry ice; Overnight shipping
Also Known As	CP-MSCs, P-MSCs, pMSCs, chorionic MSCs, human chorionic-plate-derived MSCs, placenta tissue-derived MSCs, human placenta cells, human placental stem cells, stem cells from placenta, and placenta stem cells
Product Use	This cell product is intended for laboratory research purposes only. Not approved for use in human subjects or for clinical, diagnostic, or therapeutic use in animals or humans.
References	Ma J, Wu J, Han L, Jiang X, Yan L, Hao J and Wang H. Comparative analysis of mesenchymal stem cells derived from amniotic membrane, umbilical cord, and chorionic plate under serum-free condition. Stem Cell Research & Therapy. 2019; 10(1):19. doi: 10.1186/s13287-018-1104-x. Passipieri JA, Kasai-Brunswick TH, Suhett G, et al. Improvement of cardiac function by placenta-derived mesenchymal stem cells does not require permanent engraftment and is independent of the insulin signaling pathway. Stem Cell Research & Therapy. 2014; 5(4):102. doi: 10.1186/scrt490. Wu M, Zhang R, Zou Q, Chen Y, Zhou M, Li X, Ran R and Chen Q. Comparison of the biological characteristics of mesenchymal stem cells derived from the human placenta and umbilical cord. Scientific Reports. 2018; 8:5014. doi: 10.1038/s41598-018-23396-1.

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Human Chorionic Plate-derived Mesenchymal Stem Cells – Female

Additional information

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